Melrose Real Estate

Welcome to Melrose, Florida – a hidden gem nestled in the heart of Alachua County! This charming town, known for its picturesque landscapes and friendly community, offers a unique blend of small-town charm and natural beauty. With its serene lakes, lush woodlands, and vibrant wildlife, Melrose is a haven for outdoor enthusiasts. Whether you enjoy fishing, hiking, or simply soaking in the sun, the area provides ample opportunities to connect with nature.

Melrose boasts a rich history, with roots dating back to the late 1800s. The town's quaint downtown area is dotted with charming shops, local eateries, and historical landmarks, creating an inviting atmosphere for residents and visitors alike. The community hosts various events throughout the year, fostering a strong sense of belonging and camaraderie among its residents.

Families will appreciate the excellent educational opportunities available in the area, with access to quality schools and community programs. The warm, welcoming vibe of Melrose makes it an ideal place to raise children or enjoy a peaceful retirement.

Conveniently located between Gainesville and Palatka, Melrose offers easy access to larger cities while maintaining its tranquil, rural character. This perfect balance allows residents to enjoy the best of both worlds – the hustle and bustle of city life and the serenity of country living.

If you're searching for a place that embodies Southern charm, community spirit, and natural beauty, look no further than Melrose, Florida. Discover your dream home in this delightful town and become part of a community that feels like family!

Newest Listings in Melrose

$399,900

3 Beds ⋅ 3 Baths ⋅ 2167055 MLS

Lakefront living with built-in income! Well-maintained home on a landscaped 1.19-acre, high-and-dry lot just minutes from downtown historic Melrose. 3 bedrooms, 3 full bathrooms (main residence is 2 bed / 2 bath, apartment is 1 bed / 1 bath), tons of storage, and an expansive screened lakefront lanai with inset hot tub! There is also a 900 sqft semi-finished basement with drywall, electrical, and plumbing. Use it for massive storage, finish it into a private office space or game room, etc. Separate built-in storage for a lawn mower or tools, plus a 1-car garage and ample driveway parking. A full efficiency apartment with kitchen, full bathroom, and laundry is currently rented for almost $1,000/mo on a month-to-month lease. Perfect passive income, in-law suite, or guesthouse. All of this in a prime location less than 30 minutes to Gainesville or Palatka and just 5 minutes from the almost 6,000-acre Lake Santa Fe public boat ramp! Welcome Home!

135 Ashley Lake Drive, Melrose

$379,000

3 Beds ⋅ 2 Baths ⋅ 2166772 MLS

Welcome to 359 SE 4th Avenue, a spacious home nestled in the desirable Seminole Ridge section of Melrose. This 3-bedroom, 2-bathroom home offers comfortable living spaces and a versatile bonus area created from the converted garage. The family room and dining area feature a cozy wood-burning fireplace, creating the perfect setting for family gatherings and entertaining. Situated on a beautiful 0.61-acre lot, the property offers natural landscaping between neighboring homes, providing added privacy and a peaceful outdoor setting. Built with concrete construction and a durable metal roof, this home offers low-maintenance living so you can spend more time relaxing and enjoying your surroundings. Recent updates include improvements to both bathrooms and new flooring throughout the main living areas. Don't miss the opportunity to make this inviting Melrose home your own. Schedule your showing today before it's gone!

359 Se 4th Avenue, Melrose

$795,000

6 Beds ⋅ 3 Baths ⋅ 2165784 MLS

Where Lake Life Meets Country Comfort 8315 Lilly Lake Road - Melrose, Florida - $795,000 Imagine waking up beneath a canopy of mature oaks, spending your afternoons beside the pool, and ending the day with the peaceful beauty of private Lake Opal just beyond your door. Welcome to a truly special Melrose retreat-an expansive 4,425-square-foot brick home nestled on 1.69 acres of picturesque lakefront property. Designed for both comfortable everyday living and unforgettable gatherings, this six-bedroom, four-bath home offers the space, flexibility, and setting today's buyers are looking for. Inside, the heart of the home is the generous kitchen and inviting family spaces, where gatherings naturally become the centerpiece of everyday life. A spacious family room flows into a dedicated game room, complete with a pool table and built-in ping-pong table-creating an ideal setting for holidays, weekend guests, or simply enjoying time together. Need room for everyone? You have it. The home includes six bedrooms, the in-law suite features its own private entrance-perfect for extended family, guests, multigenerational living, or a private home office arrangement. One bedroom offers excellent flexibility as a dedicated office, study, or creative space. Storage is anything but an afterthought. A huge pantry/storage area, large laundry room with built-in drop zone and ironing board, plus additional storage beneath the pool deck provide practical solutions for everything from everyday organization to outdoor equipment. And then there is the lifestyle. Step outside and enjoy your own private oasis with a pool, hot tub, lake views, fenced yard, dog run, RV hookup, and oversized parking. Mature trees provide shade and privacy while Lake Opal creates a beautiful backdrop for quiet mornings, weekend recreation, fishing, swimming, and sunset gatherings. With a metal roof, brick exterior, private well and septic system, this property combines enduring construction with the relaxed appeal of lake-country living. Located in the Melrose/Keystone Heights area, the property offers a peaceful retreat while remaining conveniently positioned for access to Gainesville, Ocala, St. Augustine, and Jacksonville. More Than a Home-It's a Place to Gather, Unwind & Make Memories. Whether you're looking for a spacious primary residence, a multigenerational home, a private lake retreat, or simply a property where family and friends can come together, 8315 Lilly Lake Road offers an uncommon combination of space, privacy, recreation, and waterfront living. In Law Suite is included in the 4425 SF. Come experience Lake Opal living for yourself.

8315 Lilly Lake Road, Melrose

$599,999

3 Beds ⋅ 2 Baths ⋅ 2166572 MLS

WATERFRONT LIVING ON THE CANAL TO LAKE SANTA FE! This spacious 3-bedroom, 2-bath waterfront home offers 2,301 square feet of heated and cooled living space with an ideal blend of comfort, functionality, and outdoor living. The interior features a welcoming living room, dedicated office area, dining space, and a well-appointed kitchen with prep island—perfect for everyday living and entertaining. The oversized primary bedroom is truly impressive, measuring approximately 31 feet in length and offering plenty of room to relax and unwind. Step outside to the lanai and take in peaceful waterfront views overlooking the boat house and boat lift. The outdoor living area is designed for enjoying the Florida lifestyle, featuring an inviting in-ground pool and hot tub. With canal access to Lake Santa Fe, this property offers an exceptional opportunity for boating, recreation, and waterfront enjoyment right at home. A unique combination of spacious indoor living, private outdoor amenities, and direct water access makes this Lake Santa Fe-area home a must-see.

241 Se 5th Avenue, Melrose

$180,000

2 Beds ⋅ 3 Baths ⋅ 2166324 MLS

Escape to tranquility at 134 Serenity Drive, Melrose, FL! Nestled in a quiet setting along the lakefront, this unique property offers incredible upside for the right buyer. The listing includes two separate structures: a main house with 1 bedroom and 1.5 bathrooms, plus a private cottage with 1 bedroom and 1 bathroom. A great starter project to renovate, replace, or customize into your dream home or rental income generator. Convenient location with rural charm. Sold as-is; cash or conventional rehab financing preferred.

134 Serenity Drive, Melrose

$549,000

3 Beds ⋅ 2 Baths ⋅ 2165461 MLS

A rare opportunity to enjoy 12 acres and your own private lake setting! This updated 3-bedroom, 2-bath home offers 1,656 sq ft surrounded by beautiful oaks, mature woods, and abundant wildlife including deer and turkey. The property sits on crystal-clear, sand-bottom Opal Lake, reaching approximately 40 feet deep and offering excellent fishing right outside your door. Inside, the home features luxury vinyl plank flooring, modern finishes, shiplap accents, and tongue-and-groove ceilings that add warmth and character throughout. Step outside to a large back deck with plenty of room for entertaining, relaxing, or taking in the peaceful surroundings. An outdoor shower is perfect for rinsing off after working around the property or spending the day at the lake. With 12 acres, privacy, wildlife, and private lake access, this property delivers the North Florida lifestyle that's getting harder to find.

8189 Melrose Road, Melrose

$249,900

3 Beds ⋅ 2 Baths ⋅ 2165124 MLS

New, first time set up home with an open and functional floor plan. Split bedroom plan and open kitchen, dining and living rooms. LVP flooring throughout with carpet in the second and third bedrooms. Generous counter space in the kitchen as well as an island. Come enjoy this new home with a modern look that has the perfect blend of space and privacy!

187 Lakeview Drive, Melrose

$300,000

4 Beds ⋅ 2 Baths ⋅ 2164874 MLS

This charming 4-bedroom, 2-bath home sits just a half-block from SR 100 on approximately 1.5 acres. The property features beautiful established gardens, an animal-friendly setup, a storage shed, and an enclosed garage with a laundry area and large flex space--perfect for a home gym, workshop, craft room, or additional storage. Inside, you'll find a spacious living room with plantation shutters, dining area, and additional flexible living space. The generously sized primary suite features plantation shutters, a California-style closet, and a bathroom with a large shower and vanity. Enjoy the peaceful surroundings from the welcoming front porch. Located in Clay County near the Putnam County line. Approximately 1,716 sq. ft. including the front porch.

8231 Swan Lake Road, Melrose

$398,000

2 Beds ⋅ 2 Baths ⋅ 2164259 MLS

Nestled on Island Road in Melrose, escape to your private waterfront oasis on the desirable Santa Fe Canal, with direct access to the expansive 6,000-acre Santa Fe Lake. This beautifully updated 2-bedroom, 2-bath home blends indoor comfort with outdoor Florida living-all just minutes from a public boat ramp and picnic area. Detached 2-car garage for storage, projects, or extra parking. Sprinkler system keeps the landscape lush with minimal effort. Canal-side deck ideal for cookouts, fishing, or relaxing by the water. Recent major updates: HVAC (2023), water heater (2024) plus many more recent improvements throughout. Vaulted ceiling with a stone-accent gas fireplace creates a warm, open great room. Split bedroom floor plan for privacy and flexibility. Enclose sunroom-perfect for morning coffee or enjoying outdoors from inside.

5930 Island Road, Melrose

$499,900

7 Baths ⋅ 2163309 MLS ⋅ Believers Harvest Time Ministries Inc. BLDG.

What a gathering place this could be! Currently used as a House of Worship, this unique property offers approximately 3,750 square feet of versatile space in a peaceful rural setting. Built in 2016, the thoughtfully designed layout provides flexibility for a growing congregation, ministry, community organization, wedding or event venue or other potential uses. Original building plans show the potential for future expansion behind the pulpit area, offering an opportunity to grow as your needs evolve. The property features ample parking, accessible entry for all, and a large covered entrance that provides a warm and welcoming arrival. All furnishings convey with the sale, making this an exceptional turn-key opportunity for a congregation looking for a place to call home.

1038 County Rd 315, Melrose

$74,900

2162497 MLS

One of two adjoining lots on a paved road that measure over one acre each. Buy one or both and plan your forever homestead! Conveniently located between Keystone Heights and Melrose in a region renowned for freshwater lakes, endless outdoor recreation and small town warmth with every day conveniences. Keystone Heights is a quaint area with downtown shopping and eateries. Nearby state parks, airport 42J, The Rally International Driving School, electric charging stations, libraries, local events and a walking/biking trail. The adjoining lot of 1.2 acres is also listed for sale.

00000 Breezy Point Road, Melrose

$74,900

2162493 MLS

This corner property of over one acre is a blank canvas for your tailored dream home! Located between Keystone Heights and Melrose in a region renowned for freshwater lakes, endless outdoor recreation and small town warmth with everyday conveniences. Keystone Heights is a quaint area with downtown shopping and eateries. Nearby state parks, airport 42J, The Rally International Driving School, electric charging stations, libraries, local events and a walking/biking trail. The adjoining lot of 1.157 acres is also listed for sale should you desire more property for your future homestead!

0000 Breezy Point Road, Melrose

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The data relating to real estate listings on this website comes in part from the Internet Data Exchange (IDX) program of Multiple Listing Service of Southern Arizona. IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Listings provided by brokerages other than Integrity One Properties are identified with the MLSSAZ IDX Logo. All Information Is Deemed Reliable But Is Not Guaranteed Accurate. Listing information Copyright 2026 MLS of Southern Arizona. All Rights Reserved.